Michael Elowitz
Roscoe Gilkey Dickinson Professor of Biology and Bioengineering; Investigator, Howard Hughes Medical Institute
B.A., University of California, 1992; M.A., Ph.D., Princeton University, 1999. Assistant Professor, Caltech, 2003-09; Bren Scholar, 2003-09; Associate Professor, 2009-10; Professor, 2010-24; Dickinson Professor, 2024-; HHMI Investigator, 2008-; Executive Officer, 2013-20.
Research Overview
Professor Elowitz's research focuses on creating and analyzing biological "circuits" of interacting genes and proteins. By programming new functions in living cells, his group seeks to uncover fundamental principles of circuit design and develop next generation cell and gene therapies. Recent work focuses on circuits that provide key functions required for multicellularity, including computation, communication, and memory.
Research Summary:
systems biology, synthetic biology, gene regulation networks, gene circuit dynamics, computational biology, single-cell biology, cell signaling, bacteria, mammalian cells, embryonic stem cells
Publications
- Askary, Amjad;Chen, Wei et al. (2025) The lives of cells, recordedNature Reviews Genetics
- Hadas, Ron;Rubinstein, Hernan et al. (2024) Temporal BMP4 effects on mouse embryonic and extraembryonic developmentNature
- Xia, Shiyu;Lu, Andrew C. et al. (2024) Synthetic protein circuits for programmable control of mammalian cell deathCell
- Tran, Martin;Askary, Amjad et al. (2024) Lineage motifs as developmental modules for control of cell type proportionsDevelopmental Cell
- Flynn, Michael James;Mayfield, Acacia M. et al. (2024) Synthetic dosage-compensating miRNA circuits allow precision gene therapy for Rett syndromebioRxiv
- Du, Rongrong;Flynn, Michael J. et al. (2024) miRNA circuit modules for precise, tunable control of gene expressionbioRxiv
- Granados, Alejandro A.;Kanrar, Nivedita et al. (2024) Combinatorial expression motifs in signaling pathwaysCell Genomics
- Ma, Yitong;Budde, Mark W. et al. (2023) Tuning Methylation-Dependent Silencing Dynamics by Synthetic Modulation of CpG DensityACS Synthetic Biology
- Horns, Felix;Martinez, Joe A. et al. (2023) Engineering RNA export for measurement and manipulation of living cellsCell
- Zhu, Ronghui;Santat, Leah A. et al. (2023) Reconstitution of morphogen shuttling circuitsScience Advances