Solving Pieces of the Genetic Puzzle
05-09-18
Postdoctoral scholar Nathan Belliveau working in the laboratory of Professor Rob Phillips has applied a method called Sort-Seq to mutate small pieces of noncoding regions in E. coli and determined which regions contain binding sites. Binding sites are the locations where specialized proteins that are involved in transcription—the first step in the process of gene expression—attach to DNA. "Humans have such a wide variety of cells—muscle cells, neurons, photoreceptors, blood cells, to name a few," says Professor Phillips. "They all have the same DNA, so how do they each turn out so differently? The answer lies in the fact that genes can be regulated—turned on or off, dialed up and dialed down—differently in different tissues. Until now, there have been no general principles to help us understand how this regulation was encoded." [Caltech story]
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Rob Phillips
APh
postdocs
Nathan Belliveau
Building Blocks to Create Metamaterials
01-17-18
Chiara Daraio, Professor of Mechanical Engineering and Applied Physics, and colleagues have created a method to systematically design metamaterials using principles of quantum mechanics. "Before our work, there was no single, systematic way to design metamaterials that control mechanical waves for different applications," Professor Daraio says. "Instead, people often optimized a design to fulfill a specific purpose, or tried out new designs based on something they saw in nature, and then studied what properties would arise from repeated patterns." [Caltech story]
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Chiara Daraio
MCE
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Two Holograms in One Surface
12-11-17
Andrei Faraon, Assistant Professor of Applied Physics and Materials Science, graduate student Seyedeh Mahsa Kamali, and colleagues have figured out a way to encode more than one holographic image in a single surface without any loss of resolution. The team developed silicon oxide and aluminum surfaces studded with tens of millions of tiny silicon posts, each just hundreds of nanometers tall. Each nanopost reflects light differently due to variations in its shape and size, and based on the angle of incoming light. [Caltech story]
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Andrei Faraon
APh
Seyedeh Mahsa Kamali
The Microscopic Origin of Efficiency Droop in LEDs
11-20-17
Marco Bernardi, Assistant Professor of Applied Physics and Materials Science, and his colleagues’ semiconductor research has shown that the coupling between electrons and thermal vibrations may be sapping energy from Light-emitting diodes—or LEDs. "Our work shows for the first time that the ever-present interaction between electrons with lattice vibrations can, by itself, explain why excited electrons can leak out of the active layer and account for inefficiencies in GaN LEDs," Professor Bernardi says. [Caltech story]
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Marco Bernardi
Reflective Nanostructures
07-13-17
Andrei Faraon, Assistant Professor of Applied Physics and Materials Science, and colleagues have discovered how to use computer-chip manufacturing technologies to create the kind of reflective materials that make safety vests, running shoes, and road signs appear shiny in the dark. The new technology uses surfaces covered by a metamaterial consisting of millions of silicon pillars, each only a few hundred nanometers tall. By adjusting the size of the pillars and the spacing between them, Faraon can manipulate how the surface reflects, refracts, or transmits light. [Caltech story]
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Andrei Faraon
