Michael Roukes and Akshay Naik Create First Nanoscale Mass Spectrometer

Michael L. Roukes, Professor of Physics, Applied Physics, and Bioengineering; Co-Director, Kavli Nanoscience Institute, and colleague Akshay Naik have created the first nanoscale mass spectrometer. This new technique simplifies and miniaturizes the measurement of the mass of molecules through the use of very tiny nanoelectromechanical system (NEMS) resonators. Askshay Naik explains, "the frequency at which the resonator vibrates is directly proportional to its mass. When a protein lands on the resonator, it causes a decrease in the frequency at which the resonator vibrates and the frequency shift is proportional to the mass of the protein." Professor Roukes points out, "the next generation of instrumentation for the life sciences must enable proteomic analysis with very high throughput. The potential power of our approach is that it is based on semiconductor microelectronics fabrication, which has allowed creation of perhaps mankind's most complex technology." [Caltech Press Release]